Which component is associated with ester-type local anesthetics and can lead to allergic reactions?

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Multiple Choice

Which component is associated with ester-type local anesthetics and can lead to allergic reactions?

Ester-type local anesthetics are broken down by esterases into para-aminobenzoic acid, or PABA. In some individuals, PABA can act as an allergen and trigger hypersensitivity reactions. That connection between the ester-derived metabolite and allergic responses is why PABA is the component associated with ester-type anesthetics’ allergies. Amide-type anesthetics, like lidocaine, do not produce PABA, so they aren’t linked to this particular allergenic pathway.

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